We have located links that may give you full text access.
Allergies and the subsequent risk of cancer among elderly adults in the United States.
Cancer Epidemiology, Biomarkers & Prevention 2019 January 31
BACKGROUND: Allergic conditions may prevent some cancers by promoting immune surveillance. We examined associations of allergic rhinitis, asthma, and eczema with cancer risk among elderly Americans.
METHODS: We used Surveillance, Epidemiology, and End Results (SEER)-Medicare linked data to perform a case-control study. Cases were individuals with first cancer diagnosed in SEER registries (1992-2013, ages 66-99; N=1,744,575). Cancer-free controls (N=100,000) were randomly selected from Medicare, matched on sex, age and selection year. Allergic conditions were identified using Medicare claims, and logistic regression was used to estimate adjusted odds ratios (aORs) with significance gauged with a Bonferroni p-value cutoff (p<0.00034).
RESULTS: Allergic rhinitis, asthma, and eczema were present in 8.40%, 3.45%, and 0.78% of controls, respectively. For allergic rhinitis, strong inverse associations (aORs 0.66-0.79) were observed for cancers of the hypopharynx, esophagus (squamous cell), cervix, tonsil/oropharynx, and vagina/vulva. More modest but significant inverse associations were noted for cancers of the esophagus (adenocarcinoma), stomach, colon, rectosigmoid/rectum, liver, gallbladder, lung, uterus, bladder, and miscellaneous sites. Associations were stronger in analyses requiring a dispensed medication to confirm the presence of allergic rhinitis. Asthma was associated with reduced risk of liver cancer (aOR 0.82, 95%CI 0.75-0.91), while eczema was associated with elevated risk of T-cell lymphoma (aOR 4.12, 3.43-4.95).
CONCLUSIONS: Inverse associations with allergic rhinitis are present for multiple cancers and require etiologic investigation.
IMPACT: Understanding of mechanisms by which allergic conditions reduce cancer risk may advance cancer prevention and treatment.
METHODS: We used Surveillance, Epidemiology, and End Results (SEER)-Medicare linked data to perform a case-control study. Cases were individuals with first cancer diagnosed in SEER registries (1992-2013, ages 66-99; N=1,744,575). Cancer-free controls (N=100,000) were randomly selected from Medicare, matched on sex, age and selection year. Allergic conditions were identified using Medicare claims, and logistic regression was used to estimate adjusted odds ratios (aORs) with significance gauged with a Bonferroni p-value cutoff (p<0.00034).
RESULTS: Allergic rhinitis, asthma, and eczema were present in 8.40%, 3.45%, and 0.78% of controls, respectively. For allergic rhinitis, strong inverse associations (aORs 0.66-0.79) were observed for cancers of the hypopharynx, esophagus (squamous cell), cervix, tonsil/oropharynx, and vagina/vulva. More modest but significant inverse associations were noted for cancers of the esophagus (adenocarcinoma), stomach, colon, rectosigmoid/rectum, liver, gallbladder, lung, uterus, bladder, and miscellaneous sites. Associations were stronger in analyses requiring a dispensed medication to confirm the presence of allergic rhinitis. Asthma was associated with reduced risk of liver cancer (aOR 0.82, 95%CI 0.75-0.91), while eczema was associated with elevated risk of T-cell lymphoma (aOR 4.12, 3.43-4.95).
CONCLUSIONS: Inverse associations with allergic rhinitis are present for multiple cancers and require etiologic investigation.
IMPACT: Understanding of mechanisms by which allergic conditions reduce cancer risk may advance cancer prevention and treatment.
Full text links
Trending Papers
A Personalized Approach to the Management of Congestion in Acute Heart Failure.Heart International 2023
Potential Mechanisms of the Protective Effects of the Cardiometabolic Drugs Type-2 Sodium-Glucose Transporter Inhibitors and Glucagon-like Peptide-1 Receptor Agonists in Heart Failure.International Journal of Molecular Sciences 2024 Februrary 21
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app