Reproducibility of Quantitative Systems Pharmacology (QSP) Models: Current Challenges and Future Opportunities.

Provision of model code is required for publication in CPT:PSP, enabling QSP model availability. A searchable repository of published QSP models would enhance model accessibility. We assess the feasibility of establishing such a resource, based on 18 QSP models published in this journal. However, due to the diversity of software platforms (9), file formats and functionality, such a resource is pre-mature. We evaluated 12 of the models (those coded in R, PK-Sim/MOBI and Matlab) for functionality. Of the 12, only 4 were executable, in that figures from the associated manuscript could be generated via a 'run' script. Many researchers are aware of the challenges involved in re-purposing published models. We offer some ideas to enable model sharing going forward, including annotation guidelines, standardized formats, and inclusion of 'run' scripts. If practitioners can agree to some minimum standards for provision of model code, this would accelerate model re-use and extension. This article is protected by copyright. All rights reserved.