We have located links that may give you full text access.
English Abstract
Journal Article
[Relationship between blood pressure variability and target organ damage in children with essential hypertension].
Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics 2019 Februrary 3
Objective: To investigate the correlation between blood pressure variability (BPV) and target organ damage in children with essential hypertension. Methods: A retrospective review identified 144 children (104 boys (72.2%) and 40 girls (27.8%), age (11.7±2.5)years) diagnosed with essential hypertension at Children's Hospital Affiliated to Capital Institute of Pediatrics from January 2013 to June 2018. Data on indicators for assessing fundus, cardiac, and renal damages obtained included 24-hour ambulatory blood pressure monitoring, BPV, fundus oculi examination, electrocardiogram, echocardiography, renal function, 24-hour urine protein quantitation, urine microalbumin, serum and urine β(2)-microglobulin. According to the existence of target organ damage, subjects were divided into target organ damage group and non-target organ damage group. Comparison between groups was analyzed using independent sample t test, chi square test and pearson correlation analysis. Results: The study included 144 children. There were 108 children (75.0%) diagnosed with phase 1 hypertension and 36 children (25.0%) diagnosed with phase 2 hypertension. Patients in target organ damage group ( n= 86, 59.7%) had a higher coefficient of 24 h diastolic BPV (14.5%±3.2% vs. 13.2%±2.5% t =2.558, P =0.012), a higher coefficient of daytime systolic BPV (8.2%±2.1% vs . 7.4%±2.0%, t= 2.253, P= 0.026) and a higher coefficient of daytime diastolic BPV (12.8%±3.4% vs. 11.1%±2.4%, t= 3.188, P= 0.002) compared with patients in non-target organ damage group ( n= 58, 40.3%). The coefficients of daytime systolic BPV and daytime diastolic BPV were significantly associated with cardiac damage ( r= 0.190, P= 0.023; r= 0.366, P< 0.01) and renal damage ( r= 0.167, P= 0.046; r= 0.167, P= 0.045). The coefficient of daytime diastolic BPV was positively correlated with left ventricular mass index ( r= 0.366, P< 0.01). Conclusions: There is a correlation between BPV and target organ damage in children with essential hypertension. Daytime BPV is strongly associated with cardiac and renal damage, and daytime diastolic BPV may predict early cardiac hypertrophy. As a noninvasive method, daytime BPV can provide evidence for early identification of hypertensive target organ damage.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app