Intelligent Computer Systems for Multiple Sclerosis Diagnosis: a Systematic Review of Reasoning Techniques and Methods.

Objective: Intelligent computer systems are used in diagnosing Multiple Sclerosis and help physicians in the accurate and timely diagnosis of the disease. This study focuses on a review of different reasoning techniques and methods used in intelligent systems to diagnose MS and analyze the application and efficiency of different reasoning methods in order to find the most efficient and applicable methods and techniques for MS diagnosis.

Methods: A complete research was carried out on articles in various electronic databases based on Mesh vocabulary. 85 articles out of 614 articles published in English between 2000 to 2018 were analyzed, 30 of which have been selected based on inclusion criteria such as system scope and domain, full description of reasoning method and system evaluation.

Results: Results indicate that different reasoning methods are used unintelligent systems of MS diagnosis. In 27% of the studies, the rule-based method was used, in 20% the fuzzy logic method, in 18%the artificial neural network method, and in 35% other reasoning methods were used. The average sensitivity, specificity and accuracy of reasoning methods were0.91, 0.77, and 0.86, respectively.

Conclusions: Rule-based, fuzzy-logic and artificial neural network methods have had more applications in intelligent systems for the diagnosis of MS, respectively. The highest rate of sensitivity and accuracy indexes is associated to the neural network reasoning method at 0.97 and 0.99, respectively .In the fuzzy logic method, the Kappa rate has been reported as one, which shows full conformity between software diagnosis and the physician's decision .In some articles, in order to remove the limitations of the methods and enhance their efficiency, combinations of different methods are used.