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Oral delivery of probiotics using pH-sensitive phthalyl inulin tablets.

Probiotics show low cell viability after oral administration because they have difficulties surviving in the stomach due to low pH and enzyme. For the oral delivery of probiotics, developing a formula to protect the probiotic bacteria from gastric acidity and provide living cells are mandatory. In this study, we developed tablets using a new pH-sensitive phthalyl inulin (PI) to protect probiotic from the gastric conditions and investigated the effects of different compression forces on cell survival. We made three different tablets under different compression forces and checked the survivability, disintegration time, and kinetics in simulated gastric-intestinal fluid. During tableting, there was no significant differences in probiotic viability among the different compression forces although disintegration time was affected by the compression force. A higher compression force resulted in higher viability in simulated gastric fluid. The swelling degree of PI tablet in simulated intestinal fluid was higher than that of in simulated gastric fluid due to the pH sensitivity of the PI. The probiotic viability formulated in the tablets displayed higher in the acidic gastric condition than probiotics in solution. Rapid release of the probiotics from the tablet occurred in the simulated intestinal fluid due to the pH sensitivity. After 6 months of refrigeration, the viability of the PI probiotics was kept. Overall, this is the first to show the pH-sensitive properties of PI and can be used for oral delivery of the probiotics.

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