α-Tetralonyl Glucosides from the Green Walnut Husks of Juglans mandshurica and Their Antiproliferative Effects.

Two new α -tetralonyl glucosides, (4 S )-4,5,8-trihydroxy- α -tetralone-5- O - β -D-glucopyranosyl(1 → 6)- β -D-glucopyranoside (1: ) and (4 S )-4,8-dihydroxy- α -tetralone-4- O - β -D-glucopyranosyl(1 → 6)- β -D-glucopyranoside (2: ), together with eight known compounds (3:  - 10: ) were isolated from the green walnut husks of Juglans mandshurica . The structural characterization of all compounds was performed by spectroscopic analyses, including 1D and 2D NMR and HR-ESI-MS experiments. The isolated compounds were assayed for their cytotoxicity against two human cancer cell lines, A549 and HeLa. Four compounds (7:  - 10: ) exhibited inhibitory effects against two human cancer cell lines with GI50 values between 1.3 and 5.8 µM.