JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Add like
Add dislike
Add to saved papers

Self-Propelled and Targeted Drug Delivery of Poly(aspartic acid)/Iron-Zinc Microrocket in the Stomach.

ACS Nano 2019 Februrary 27
For many medical treatments, particularly cancer, it is necessary to develop a biocompatible microscale device that can carry a sufficient amount of a drug and deliver it to target sites. While chemically powered micromotors have been applied in live animal therapy, many of them are difficult to biodegrade in vivo, which might cause toxicity and side effects. Here, we report on a microdevice that consists of a poly(aspartic acid) (PASP) microtube, a thin Fe intermediate layer, and a core of Zn. This device can be propelled using gastric acid as a fuel. After adsorption of doxorubicin onto a PASP surface, the microrocket can carry drugs, magnetically locate targets, permeate the gastric mucus gel layer, and increase drug retention in the stomach without inducing an obvious toxic reaction. All materials in the microrockets are biocompatible and biodegradable and can be readily decomposed by the gastric acid or by proteases in the digestive tract. Such microrockets, made with poly(amino acid)s, will extend the practical biomedical applications of micro- and nanomotors.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app