Add like
Add dislike
Add to saved papers

Efficacy and Safety of Genotype-Guided Warfarin Dosing in the Chinese Population: A Meta-analysis of Randomized Controlled Trials.

AIMS: To evaluate the efficacy and safety of using genetic information to guide warfarin dosing in the Chinese population.

METHODS: This meta-analysis was conducted among the published, randomized, controlled trials (RCTs) in the Chinese population comparing genotyped-guided warfarin dosing (PG group) with clinical or standard warfarin dosing (STD group). RCTs published on or before January 2018 were identified using the PubMed, Embase, Cochrane Library, CNKI, Chinese VIP database and Chinese Wanfang databases.

RESULT: The 2,137 participants from 14 RCTs were included in the meta-analysis. Primary analysis showed that both bleeding events (OR=0.24, 95% CI, 0.11 to 0.52, P=0.0003) and adverse events (OR=0.60, 95% CI, 0.43 to 0.83, P=0.002) were significantly lower in the genotyped-guided group than in the clinical or standard group. The percentage of patients who received a warfarin-stable therapeutic dose during follow-up was increased in the genotyped-guided groupcompared to the percentage in the clinical or standard group (OR=2.68, 95% CI,1.82 to 3.95, P<0.00001). In the genotyped-guided group, the time to a stabletherapeutic dose (MD=-7.98, 95% CI, -9.08 to -6.87, p<0.00001) and the time to the first target value (MD=-1.87, 95% CI, -3.41 to -0.32, P=0.02) were shortened compared with those of the clinical or standard group, but there was nodifference for INR>4, between the two groups (OR=0.42, 95% CI, 0.14 to 1.25, P=0.12).

CONCLUSION: Genotype-guided warfarin dosing algorithms could improve the efficacy and safety of warfarin anticoagulation in the Chinese population.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app