Using Naïve Bayes algorithm to estimate the response to drug in lung cancer patients.

AIM AND OBJECTIVE: Lung cancer is a highly heterogeneous cancer, due to the significant differences in molecular levels, resulting in different clinical manifestations of lung cancer patients there is a big difference. Including disease characterization, drug response, risk of recurrence, survival, etc. Method: Clinical patients with lung cancer is not yet particularly effective treatment options, while patients with lung cancer resistance not only delayed the treatment cycle, but also caused a strong side effects. Therefore, if we can sum up the abnormalities of functional level from the molecular level, we can scientifically and effectively evaluate the patients' sensitivity to treatment and make the personalized treatment strategies to avoid the side effects caused by over-treatment and improve the prognosis.

RESULT & CONCLUSION: According to the different sensitivities of lung cancer patients to drug response, this study screened out genes that were significantly associated with drug resistance. The bayes model was used to assess patient resistance.