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Preliminary Study on the Relationship between Inflammation and Hemifacial Spasm.
World Neurosurgery 2019 January 24
BACKGROUND: The complete pathogenesis of hemifacial spasm (HFS) remains unknown. Some patients with HFS have shown the thickened, opaque and sticky arachnoid membranes during microvascular decompression (MVD) procedures. This phenomenon indicates a possible relationship between inflammation and HFS. However, few studies have focused on it. This study aims to explore the role of inflammation in pathogenesis of HFS.
METHODS: The levels of interferon gamma (IFN-γ), interleukin 2 receptor (IL-2R), interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 10 (IL-10) and tumor necrosis factor alpha (TNF-α), white blood cell (WBC), neutrophil and lymphocyte were compared between HFS patients, lumbar disc herniation (LDH) patients and healthy participants. A receiver operating characteristics (ROC) curve analysis was performed to evaluate the diagnostic significance of the peripheral blood inflammatory markers for HFS. In addition, all the inflammatory markers were further analyzed by single and multiple logistic regression analysis.
RESULTS: Patients with HFS had the greater IL-6, IL-8, WBC count and neutrophil count than those without. The area under curve (AUC) values of IL-6, WBC and neutrophil were greater than 0.8. Multiple logistic regression analysis indicated that only IL-2R and IL-6 were relevant to HFS.
CONCLUSIONS: Inflammation is relative to HFS. IL-6 may be one of the many factors involved in the pathogenesis of HFS.
METHODS: The levels of interferon gamma (IFN-γ), interleukin 2 receptor (IL-2R), interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 10 (IL-10) and tumor necrosis factor alpha (TNF-α), white blood cell (WBC), neutrophil and lymphocyte were compared between HFS patients, lumbar disc herniation (LDH) patients and healthy participants. A receiver operating characteristics (ROC) curve analysis was performed to evaluate the diagnostic significance of the peripheral blood inflammatory markers for HFS. In addition, all the inflammatory markers were further analyzed by single and multiple logistic regression analysis.
RESULTS: Patients with HFS had the greater IL-6, IL-8, WBC count and neutrophil count than those without. The area under curve (AUC) values of IL-6, WBC and neutrophil were greater than 0.8. Multiple logistic regression analysis indicated that only IL-2R and IL-6 were relevant to HFS.
CONCLUSIONS: Inflammation is relative to HFS. IL-6 may be one of the many factors involved in the pathogenesis of HFS.
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