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28 days follow up of patch-test reactions to p-phenylenediamine and p-phenylenediamine dihydrochloride: a multicenter study on behalf of EECDRG.

Contact Dermatitis 2019 January 27
BACKGROUND: It is discussed if routinely patch testing p-phenylenediamine (PPD) 1.0 % petrolatum is safe due to the risk of patch test sensitization. Late appearing patch test reactions may reflect patch test sensitization, but may also be due to a low degree of pre-existing sensitization.

OBJECTIVES: The aim of this study was to follow the positive patch test reactions to PPD and its salt PPD-dihydrochloride (PPD-DHC) to characterize reaction patterns concerning time and dose in PPD-sensitized individuals.

METHODS: Volunteers with previous reactions to PPD 1.0% were included and patch tested with PPD and PPD-DHC in equimolar dilution series. Seven follow-up visits during 28 days followed.

RESULTS: Twenty-six volunteers completed the study of which 23/26 (88%) reacted to PPD 1.0%, whereas 69% reacted to 0.32%. Altogether, 42% and 27% reacted to the corresponding equimolar concentrations of PPD-DHC. After day 7 no new reactions were observed to any concentration tested, neither of PPD nor of PPD-DHC.

CONCLUSION: No late appearing reactions were observed to PPD or PPD-DHC at any dose. There is a risk of missing contact allergy when the dose was decreased. This article is protected by copyright. All rights reserved.

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