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JOURNAL ARTICLE
REVIEW
TGF-β in Pancreatic Disease: Mechanisms and Therapeutic Potential.
Pharmacological Research : the Official Journal of the Italian Pharmacological Society 2019 January 23
Pancreatic disease, such as acute pancreatitis (AP), chronic pancreatitis (CP) and pancreatic cancer (PC), is a common gastrointestinal disease resulting in the development of local and systemic complications with a significant risk of death. A host of studies on pancreatic disease have been conducted over the past few decades, however, the pathogenesis remains obscure, and there is still a lack of effective treatment options. Recently, there are emerging evidences that transforming growth factor beta (TGF-β) exerts controversial function in apoptosis, inflammatory response and carcinogenesis, which makes its roles more complex in the pathogenesis of pancreas-associated disease. Therefore, further understanding of relevant TGF-β signaling will provide new idea and potential therapeutic targets that can prevent disease progression. Here, as far as we know, we are the first one to systemically review recent data from animal and human clinical studies that focus on TGF-β signaling in a set of pancreas damage and disease, and the potentially promising development of therapeutic agents to regulate TGF-β on this pathology for preventing or treating pancreatic disease.
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