A Widely Applicable AIE Chemosensor for On-site Fast Detection of Drugs Based on POSS-core Dendrimer with Controlled Self-assembly Mechanism.

A novel fluorescence chemosensor quickly detecting synthetic drugs for on-site check and pre-screening is firstly reported. An eight tetraphenylethene (TPE) modified polyhedral oligomeric silsesquioxane (POSS) dendrimer is designed and synthesized as an aggregation-induced emission (AIE) chemosensor, which exhibits great enchancement of unique monomer emission in pure tetrahydrofuran (THF) and AIE emission in THF/water thanks to forming different self-assembly morphologies. And POSS-TPE can sensitively detect methamphetamine and ketamine even in artificial saliva by non-covalent interaction forces. It has great potential to be a new widely applicable AIE chemosensor for aromatics molecules.