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JOURNAL ARTICLE
REVIEW

Long non-coding RNAs in hematopoietic regulation

Weiqian Li, Yue Ren, Yanmin Si, Fang Wang, Jia Yu
Cell Regeneration 2018, 7 (2): 27-32
30671227
Long non-coding RNAs (lncRNAs) have crucial roles via tethering with DNA, RNA or protein in diverse biological processes. These lncRNA-mediated interactions enhance gene regulatory networks and modulate a wide range of downstream genes. It has been demonstrated that several lncRNAs act as key regulators in hematopoiesis. This review highlights the roles of lncRNAs in normal hematopoietic development and discusses how lncRNA dysregulation correlates with disease prognoses and phenotypes.

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