JOURNAL ARTICLE
RESEARCH SUPPORT, N.I.H., EXTRAMURAL
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.
Tuomas O Kilpeläinen, Amy R Bentley, Raymond Noordam, Yun Ju Sung, Karen Schwander, Thomas W Winkler, Hermina Jakupović, Daniel I Chasman, Alisa Manning, Ioanna Ntalla, Hugues Aschard, Michael R Brown, Lisa de Las Fuentes, Nora Franceschini, Xiuqing Guo, Dina Vojinovic, Stella Aslibekyan, Mary F Feitosa, Minjung Kho, Solomon K Musani, Melissa Richard, Heming Wang, Zhe Wang, Traci M Bartz, Lawrence F Bielak, Archie Campbell, Rajkumar Dorajoo, Virginia Fisher, Fernando P Hartwig, Andrea R V R Horimoto, Changwei Li, Kurt K Lohman, Jonathan Marten, Xueling Sim, Albert V Smith, Salman M Tajuddin, Maris Alver, Marzyeh Amini, Mathilde Boissel, Jin Fang Chai, Xu Chen, Jasmin Divers, Evangelos Evangelou, Chuan Gao, Mariaelisa Graff, Sarah E Harris, Meian He, Fang-Chi Hsu, Anne U Jackson, Jing Hua Zhao, Aldi T Kraja, Brigitte Kühnel, Federica Laguzzi, Leo-Pekka Lyytikäinen, Ilja M Nolte, Rainer Rauramaa, Muhammad Riaz, Antonietta Robino, Rico Rueedi, Heather M Stringham, Fumihiko Takeuchi, Peter J van der Most, Tibor V Varga, Niek Verweij, Erin B Ware, Wanqing Wen, Xiaoyin Li, Lisa R Yanek, Najaf Amin, Donna K Arnett, Eric Boerwinkle, Marco Brumat, Brian Cade, Mickaël Canouil, Yii-Der Ida Chen, Maria Pina Concas, John Connell, Renée de Mutsert, H Janaka de Silva, Paul S de Vries, Ayşe Demirkan, Jingzhong Ding, Charles B Eaton, Jessica D Faul, Yechiel Friedlander, Kelley P Gabriel, Mohsen Ghanbari, Franco Giulianini, Chi Charles Gu, Dongfeng Gu, Tamara B Harris, Jiang He, Sami Heikkinen, Chew-Kiat Heng, Steven C Hunt, M Arfan Ikram, Jost B Jonas, Woon-Puay Koh, Pirjo Komulainen, Jose E Krieger, Stephen B Kritchevsky, Zoltán Kutalik, Johanna Kuusisto, Carl D Langefeld, Claudia Langenberg, Lenore J Launer, Karin Leander, Rozenn N Lemaitre, Cora E Lewis, Jingjing Liang, Jianjun Liu, Reedik Mägi, Ani Manichaikul, Thomas Meitinger, Andres Metspalu, Yuri Milaneschi, Karen L Mohlke, Thomas H Mosley, Alison D Murray, Mike A Nalls, Ei-Ei Khaing Nang, Christopher P Nelson, Sotoodehnia Nona, Jill M Norris, Chiamaka Vivian Nwuba, Jeff O'Connell, Nicholette D Palmer, George J Papanicolau, Raha Pazoki, Nancy L Pedersen, Annette Peters, Patricia A Peyser, Ozren Polasek, David J Porteous, Alaitz Poveda, Olli T Raitakari, Stephen S Rich, Neil Risch, Jennifer G Robinson, Lynda M Rose, Igor Rudan, Pamela J Schreiner, Robert A Scott, Stephen S Sidney, Mario Sims, Jennifer A Smith, Harold Snieder, Tamar Sofer, John M Starr, Barbara Sternfeld, Konstantin Strauch, Hua Tang, Kent D Taylor, Michael Y Tsai, Jaakko Tuomilehto, André G Uitterlinden, M Yldau van der Ende, Diana van Heemst, Trudy Voortman, Melanie Waldenberger, Patrik Wennberg, Gregory Wilson, Yong-Bing Xiang, Jie Yao, Caizheng Yu, Jian-Min Yuan, Wei Zhao, Alan B Zonderman, Diane M Becker, Michael Boehnke, Donald W Bowden, Ulf de Faire, Ian J Deary, Paul Elliott, Tõnu Esko, Barry I Freedman, Philippe Froguel, Paolo Gasparini, Christian Gieger, Norihiro Kato, Markku Laakso, Timo A Lakka, Terho Lehtimäki, Patrik K E Magnusson, Albertine J Oldehinkel, Brenda W J H Penninx, Nilesh J Samani, Xiao-Ou Shu, Pim van der Harst, Jana V Van Vliet-Ostaptchouk, Peter Vollenweider, Lynne E Wagenknecht, Ya X Wang, Nicholas J Wareham, David R Weir, Tangchun Wu, Wei Zheng, Xiaofeng Zhu, Michele K Evans, Paul W Franks, Vilmundur Gudnason, Caroline Hayward, Bernardo L Horta, Tanika N Kelly, Yongmei Liu, Kari E North, Alexandre C Pereira, Paul M Ridker, E Shyong Tai, Rob M van Dam, Ervin R Fox, Sharon L R Kardia, Ching-Ti Liu, Dennis O Mook-Kanamori, Michael A Province, Susan Redline, Cornelia M van Duijn, Jerome I Rotter, Charles B Kooperberg, W James Gauderman, Bruce M Psaty, Kenneth Rice, Patricia B Munroe, Myriam Fornage, L Adrienne Cupples, Charles N Rotimi, Alanna C Morrison, Dabeeru C Rao, Ruth J F LoosMany genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels.
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