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Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as hematologic indices of inflammatory response in ceramic workers' silicosis.

INTRODUCTION: Occupational exposure to crystalline silica over time may result with silicosis: a fatal, irreversible occupational disease leading to lung function impairment. A complex inflammatory process, excessive accumulation of mesenchymal cells collagen production are the primary mechanisms underlying silicosis. Neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) have emerged as representative indices of systemic inflammation.

OBJECTIVES: The purpose of the present study was to investigate the relationship between NLR, PLR and silicosis.

METHODS: We retrospectively analyzed demographic and laboratory data of ceramic workers who were referred to our Hospital between 2010 and 2018. 573 patients with silicosis and 222 ceramic workers without silicosis (controls) were included in the study.

RESULTS: The radiographic ILO classification of silicosis patients were as follows; category 1 (71.5%), category 2 (19.2%), category 3 (7.5%). NLR and PLR in category 2 and 3 were significantly higher when compared with control group (p<0.005). FEV1 , FEV1 %, FVC, FVC % and PEF were significantly lower in all silicosis patients and also in patients with subcategories (all p<0.005). NLR showed a poor positive correlation with CRP (r=0.095, p<0.05) and ESR (r=0.207, p=0.000) while PLR only with ESR (r=0.317, p=0.000) in patients. NLR and PLR showed negative correlations with FEV1 , FVC and PEF (all p<0.005).

CONCLUSION: We conclude NLR and PLR have a significant but poor correlations with pulmonary functions and severity of silicosis especially in late radiographic profusion categories. This article is protected by copyright. All rights reserved.

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