Poisson Multilevel Models with Small Samples.

Recent methodological studies have investigated the properties of multilevel models with small samples. Previous work has primarily focused on continuous outcomes and little attention has been paid to count outcomes. The estimation of count outcome models can be difficult because the likelihood has no closed-form solution, meaning that approximation methods are required. Although adaptive Gaussian quadrature (AGQ) is generally seen as the gold standard, its comparative performance has been investigated with larger samples. AGQ approximates the full likelihood, a function that is known to produce biased estimates with small samples with continuous outcomes. Conversely, penalized quasi-likelihood (PQL) is considered to be a less desirable approximation; however, it can approximate the restricted likelihood function, a function that is known to perform well with smaller samples with continuous outcomes. The goal of this paper is to compare the small sample bias of full likelihood methods to the linearization bias of PQL with restricted likelihood. Simulation results indicate that the linearization bias of PQL is preferable to the finite sample bias of AGQ with smaller samples.