We have located links that may give you full text access.
Power determination during drug development: Is optimizing the sample size based on exposure-response analyses underutilized?
CPT: Pharmacometrics & Systems Pharmacology 2019 January 19
The use of model-based drug development (MBDD) has been demonstrated to improve the efficiency of clinical trial design. However, MBDD complexity can limit its use, particularly early in clinical development. In this tutorial a simple and generalizable exposure-response analysis approach to determine the power for dose ranging studies is presented and described. We identified situations where higher power and sample size reduction is achieved by utilizing the exposure-response powering methodology compared to conventional power calculations. This article is protected by copyright. All rights reserved.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app