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F-Box Protein-Mediated Resistance to PARP Inhibitor Therapy.

Aleksandra I Adamovich, Amanda Ewart Toland, Jeffrey D Parvin
Molecular Cell 2019 January 18
PARP inhibitor (PARPi) therapy targets BRCA1/2 mutant tumor cells, but acquired resistance limits its effectiveness. In this issue of Molecular Cell, Marzio et al. (2019) identify a novel mechanism of resistance to PARPi through regulation of RAD51 protein stability via an SCF ubiquitin ligase dependent on EMI1.

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