Low-dose curcuminoid-loaded in dextran nanobubbles can prevent metastastatic spreading in prostate cancer cells.

Preventing recurrences and metastasis of Prostate Cancer after prostatectomy by administering adjuvant therapies is a quite controversial issue. In addition to effectiveness, absence of side effects and long term toxicity are mandatory. Curcuminoids (Curc) extracted with innovative techniques and effectively loaded by polymeric nanobubbles (Curc-NBs) satisfy such requirements. Curc-NBs showed stable over 30 days, were effectively internalized by tumor cells and were able to slowly release Curc in a sustained way. Significant biological effects were detected in PC-3 and DU-145 cell lines where Curc-NBs were able to inhibit adhesion and migration, to promote cell apoptosis and to affect cell viability and colony-forming capacity in a dose-dependent manner. 
 Since the favourable effects are already detectable at very low doses, which can be reached at clinical level, and the actual drug concentration can be visualized and monitored by US or MRI, Curc-NBs can be proposed as an effective adjuvant theranostic tool. &#13.