Ultrasmall MoS2 Nanodots Doped Biodegradable SiO2 Nanoparticles for Clearable FL/CT/MSOT Imaging Guided PTT/PDT Combination Tumor therapy.

Recently, we developed ultrasmall molybdenum disulfide (MoS2) quantum dots for computed tomography (CT) and multispectral optoacoustic tomography (MSOT) image-guided phuotothermal therapy (PTT). But, due to the rapid body elimination and the limited blood circulation time, the tumor uptake of the dots is low. In our study, this problem was solved via designing an amino modified biodegradable nanomaterial based on MoS2 quantum dots doped disulfide-based SiO2 nanoparticles (denoted MoS2@ss-SiO2) for multimodal application. By integrating the MoS2 quantum dots into clearable SiO2 nanoparticles, this nanoplatform with an appropriate particle size can not only degrade and excrete in a reasonable period induced by the redox-responsive with the glutathione (GSH), but also exhibits a high tumor uptake due to the longer blood circulation time. Moreover, hyaluronic acid (HA) and chlorin e6 (Ce6) were adsorbed on the outer shell for the tumor targeting effect and photodynamic therapy, respectively. So this biodegradable and clearable theranostic nanocomposite applicable in integrated fluorescence(FL)/CT/MSOT imaging guided combined photothermal therapy (PTT) and photodynamic therapy (PDT) is very optimistic in biomedical applications in the future.