Screening of the Pathogen Box reveals new starting points for anti-trypanosomal drug discovery.

This study aimed to uncover new starting points for anti-trypansomal drug discovery through the screening of the Pathogen Box against Trypanosoma brucei brucei . Our study identified compounds 35 , 39 , 46 , 53 and 56 whose activity and selectivity highlighted them as promising candidates with potential for further study and optimisation.