Aspirin does not prevent pancreatic cancer in a large Asian cohort.

Min-Hyung Kim, Sang Min Park, Young Ho Yun, In Cheol Hwang

Cancer Epidemiology, Biomarkers & Prevention 2019 January 15

BACKGROUND: Evidence has suggested that aspirin reduces the incidence of several cancers, but these benefits may not occur with pancreatic cancer.

METHODS: A 12-year nationwide longitudinal cohort merged with health checkup data were divided into "exposure ascertainment period" and "outcome ascertainment period" to avoid immortal time bias. The Daily Defined Dose system was used to indicate the drug exposure.

RESULTS: We found no significant association between aspirin use and incident pancreatic cancer based on hazard ratio.

CONCLUSION: Aspirin dose not prevent pancreatic cancer.

IMPACT: A large Asian cohort study with reliable medication information affirm no impact of aspirin on pancreatic cancer development.

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