We have located links that may give you full text access.
Synthesis, characterization and antidiabetic effects of vanadyl(II) adenosine monophosphate amino acid mixed-ligand complexes.
Future Medicinal Chemistry 2019 January 16
AIM: This research paper is aimed at designing a novel insulin alternative for the treatment of diabetes.
MATERIALS & METHODS: Six novel vanadyl(II) compounds, [(AMP-2 )(VO+2 )(AA n -1 )]·NH4 +1 , were synthesized from an equimolar ratio of adenosine monophosphate, VOSO4 and amino acids (AA n ).
RESULTS: The magnetic moments and electronic spectra revealed the square pyramidal geometrical structure of the complexes. In an in vivo study, the insulin levels, blood glucose levels, lipid profiles and histology of the pancreas and liver of the animals treated with the complexes were similar to those of healthy control animals, unlike the untreated and vanadyl sulfate(II)-treated diabetic ones.
CONCLUSION: The data gathered in the current research illustrated that vanadyl(II)-AMP-amino acid (AA) mixed-ligand complexes can function as antidiabetic agents.
MATERIALS & METHODS: Six novel vanadyl(II) compounds, [(AMP-2 )(VO+2 )(AA n -1 )]·NH4 +1 , were synthesized from an equimolar ratio of adenosine monophosphate, VOSO4 and amino acids (AA n ).
RESULTS: The magnetic moments and electronic spectra revealed the square pyramidal geometrical structure of the complexes. In an in vivo study, the insulin levels, blood glucose levels, lipid profiles and histology of the pancreas and liver of the animals treated with the complexes were similar to those of healthy control animals, unlike the untreated and vanadyl sulfate(II)-treated diabetic ones.
CONCLUSION: The data gathered in the current research illustrated that vanadyl(II)-AMP-amino acid (AA) mixed-ligand complexes can function as antidiabetic agents.
Full text links
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app