We have located links that may give you full text access.
The Active Ingredient of Cognitive Restoration: A Multicenter Randomized Controlled Trial of Sequential Combination of Aerobic Exercise and Computer-Based Cognitive Training in Stroke Survivors with Cognitive Decline.
Archives of Physical Medicine and Rehabilitation 2019 January 10
OBJECTIVE: To investigate the efficacy of a sequential combination of aerobic exercise and cognitive training on cognitive function and other health-related outcomes in stroke survivors with cognitive decline.
DESIGN: Intervention study and randomized controlled trial.
SETTING: Hospital-based rehabilitation units.
PARTICIPANTS: Stroke survivors with cognitive decline were randomized to sequential combination training (SEQ; n = 15) or an active control (CON; n = 15) group. Interventions The SEQ group received 30 minutes of aerobic exercise, followed by 30 minutes of computerized cognitive training. The CON group received 30 minutes of non-aerobic physical exercise, followed by 30 minutes of unstructured mental activities.
MAIN OUTCOME MEASURE: The primary outcome measure was cognitive function. Secondary outcome measures included physical function, social participation, and quality of life.
RESULTS: Compared with the CON group, the SEQ group had significantly improved Montreal Cognitive Assessment scores (p = 0.03) and Wechsler Memory Scale (Third Edition) span scores (p = 0.012) after training. The endurance and mobility level measured by the 6-Minute Walk Test (p = 0.25) was also enhanced in the SEQ group relative to the CON group. However, the transfer of sequential training to social participation (Community Integration Questionnaire) and quality of life (EuroQoL questionnaire) was limited (p > 0.05 for both).
CONCLUSIONS: Aerobic exercise combined with computerized cognitive training has better effects on the cognitive functional status of post-stroke survivors than an active control. The cognitive functional status of post-stroke survivors was better after participation in aerobic exercise combined with computerized training than after active control therapy, demonstrating the clinical significance of this combination therapy.
DESIGN: Intervention study and randomized controlled trial.
SETTING: Hospital-based rehabilitation units.
PARTICIPANTS: Stroke survivors with cognitive decline were randomized to sequential combination training (SEQ; n = 15) or an active control (CON; n = 15) group. Interventions The SEQ group received 30 minutes of aerobic exercise, followed by 30 minutes of computerized cognitive training. The CON group received 30 minutes of non-aerobic physical exercise, followed by 30 minutes of unstructured mental activities.
MAIN OUTCOME MEASURE: The primary outcome measure was cognitive function. Secondary outcome measures included physical function, social participation, and quality of life.
RESULTS: Compared with the CON group, the SEQ group had significantly improved Montreal Cognitive Assessment scores (p = 0.03) and Wechsler Memory Scale (Third Edition) span scores (p = 0.012) after training. The endurance and mobility level measured by the 6-Minute Walk Test (p = 0.25) was also enhanced in the SEQ group relative to the CON group. However, the transfer of sequential training to social participation (Community Integration Questionnaire) and quality of life (EuroQoL questionnaire) was limited (p > 0.05 for both).
CONCLUSIONS: Aerobic exercise combined with computerized cognitive training has better effects on the cognitive functional status of post-stroke survivors than an active control. The cognitive functional status of post-stroke survivors was better after participation in aerobic exercise combined with computerized training than after active control therapy, demonstrating the clinical significance of this combination therapy.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices 
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app