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SurE is a trans-acting thioesterase cyclizing two distinct non-ribosomal peptides.
Organic & Biomolecular Chemistry 2019 January 15
SurE is a new, stand-alone thioesterase (TE) offloading the non-ribosomal peptide (NRP) assembly line found in surugamide biosynthesis. It is homologous to penicillin binding protein (PBP) and capable of cyclizing two structurally unrelated substrates derived from two different NRP assembly lines, highlighting the broad substrate tolerance of the SurE offloading cyclase.
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