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Virilization in a Girl Caused by an Ovarian Yolk Sac Tumor: A Case Report.
Journal of Pediatric and Adolescent Gynecology 2019 January 8
INTRODUCTION: Yolk sac tumors (YSTs) are rare malignancies that originate from germ cells and rarely present with endocrine symptoms. We report a case of a 13-year-old girl with a YST manifesting as virilization.
CASE REPORT: A 13-year-old girl was diagnosed as a YST with endocrine symptoms because of Leydig cells in the stroma, which were identified by HE staining and immunohistochemistry.
CONCLUSION: This case suggests that clinicians should consider the possibility of YST when encountering patients with symptoms of virilization. Once a YST is found to have endocrine function, a functioning stroma could present. Immuno- histochemistry is useful for identifying stromal cells and performing a differential diagnosis.
CASE REPORT: A 13-year-old girl was diagnosed as a YST with endocrine symptoms because of Leydig cells in the stroma, which were identified by HE staining and immunohistochemistry.
CONCLUSION: This case suggests that clinicians should consider the possibility of YST when encountering patients with symptoms of virilization. Once a YST is found to have endocrine function, a functioning stroma could present. Immuno- histochemistry is useful for identifying stromal cells and performing a differential diagnosis.
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