Simulation of photon-counting detectors for conversion of dual-energy-subtracted computed tomography number to electron density.

For accurate tissue-inhomogeneity correction in radiotherapy treatment planning, the author previously proposed a conversion of the energy-subtracted computed tomography (CT) number to electron density (ΔHU-ρe conversion). The purpose of the present study was to provide a method for investigating the accuracy of a photon-counting detector (PCD) used in the ΔHU-ρe conversion by performing dual-energy CT image simulations of a PCD system with two energy bins. To optimize the tube voltage and threshold energy, the image noise and errors in ρe calibration were evaluated using three types of virtual phantoms: a 35-cm-diameter pure water phantom, 33-cm-diameter solid water surrogate phantom equipped with 16 inserts, and another solid water surrogate phantom with a 25-cm diameter. The third phantom was used to investigate the effect of the object's size on the ρe -calibration accuracy of PCDs. Two different scenarios for the PCD energy response were considered, corresponding to the ideal and realistic cases. In addition, a simple correction method for improving the spectral separation of the dual energies in a realistic PCD was proposed to compensate for its performance loss. In the realistic PCD case, there exists a trade-off between the image noise and ρe -calibration errors. Furthermore, the weakest image noise was nearly twice that for the ideal case, and the ρe -calibration error did not reach practical levels for any threshold energy. Nevertheless, the proposed correction method is likely to decrease the ρe -calibration errors of a realistic PCD to the level of the ideal case, yielding more accurate ρe values that are less affected by object size variation.