COMPARATIVE STUDY
JOURNAL ARTICLE
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Comparison of invasive and non-invasive aortic wave intensity and wave power analyses in sheep.

OBJECTIVE: Wave intensity (WI) and wave power (WP) analyses are powerful approaches for assessing ventricular-vascular interactions and arterial dynamics using invasive and non-invasive methods. However, in vivo comparison of these methods for large arteries is lacking. This study assessed agreement, correlation and relative changes in wave size in invasive and non-invasive aortic WI/WP analyses, and associated sources of error.

APPROACH: The proximal descending thoracic aorta (DTA) of nine wethers was instrumented with a micromanometer and perivascular transit-time flow probe to measure high-fidelity blood pressure (P) and flow (Q) for invasive WI/WP analyses at baseline and during haemodynamic perturbations produced by cardiac pacing, distal DTA constriction and dobutamine-induced inotropic stimulation. In 212 experimental runs, concurrent echocardiographic DTA diameter and velocity (U) data were acquired for non-invasive WI/WP analyses, with measurement of forward compression wave (FCW), backward compression wave (BCW) and forward decompression wave (FDW) cumulative intensity (CI), cumulative power (CP) and wave-related pressure changes (ΔP).

MAIN RESULTS: Although agreement between invasive and non-invasive FCW, BCW and FDW CI/CP measures was variable (bias  -84% to  +7%), correlation was good (R  =  0.66-0.84), with lower bias and higher correlation for ΔP variables and similar relative changes in FCW and BCW CI/ΔP during haemodynamic perturbations. Main error sources were overestimation of invasive U due to assumed fixed vessel diameter, inaccuracies in non-invasive Q, and non-invasive underestimation of peak P/U and Q rates of change.

SIGNIFICANCE: Despite variable agreement, non-invasive CI/CP indices correlate well with invasive measurements, and detect relative changes in major waves induced by haemodynamic perturbations.

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