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Association between miRNA-146a rs2910164 (G/C) polymorphism with the susceptibility to chronic HBV infection and spontaneous viral clearance (SVC) in an Iranian population.

Hepatitis B virus (HBV) infection is one of the clinical dilemmas in chronic liver diseases. MicroRNAs (miRNAs) are small non-codding RNA molecules that play an important role in the pathogenesis of liver diseases and single nucleotide polymorphisms (SNPs) in miRNA genes affect the clinical course of HBV infection. Previous studies have shown that miRNA-146a rs2910164 polymorphism can be associated with the pathogenesis of liver diseases such as hepatocellular carcinoma (HCC). The present study investigated the association between miRNA-146a -2 rs2910164 polymorphism and susceptibility to HBV infection in an Iranian population. The study comprised 266 patients with chronic HBV infection, 172 patients with spontaneous viral clearance (SVC) after acute HBV infection, and 266 healthy control (HCL) adjusted for gender and age. The genotyping of the miRNA-146a rs2910164 polymorphism was performed by PCR-RFLP method. Our data revealed that GG genotype and G allele of miRNA-146a rs2910164 SNP is dominated (P<0.001) in patients with chronic HBV infection (OR=3.92; 95% CI = 2.1-7.32). MiRNA-146a -2 rs2910164 polymorphism showed a statistically significant association (P<0.001) between CC genotype and allele C with spontaneous viral clearance (OR=2.92; 95% CI = 1.56-546). Our findings suggest miRNA-146a SNP (C / G) in our population may be associated with the susceptibility to HBV infection and CC genotype is associated to spontaneous viral clearance. Also, the GG genotype and G allele at miRNA-146a rs2910164 is associated with chronic HBV infection in our population. This article is protected by copyright. All rights reserved.

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