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Matrilin 2 prevents the TNFα-induced apoptosis of WB-F344 cells via suppressing JNK pathway.
Biotechnology and Applied Biochemistry 2019 January 10
Oval cells, a kind of hepatic progenitor cell quiescent at normal condition, activates to proliferate and differentiate into hepatocytes under severe and long-term liver injury, which usually raises severe inflammation. However, how oval cell survives in the inflammatory milieu interne is still unclear. TNFα, mimicking inflammatory hepatic milieu interne, was used to treat oval cell line, WB-F344, to test the protective function of matrilin 2. In this study, our data suggested that matrilin 2 prevented TNFα-induced apoptosis in WB-F344 cells via inhibiting ASK1/MKK7/JNK pathway. In conclusion, we determined that matrilin 2 plays the key role in maintaining the survival of oval cell and guarantee its proliferation under various injury factors. This article is protected by copyright. All rights reserved.
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