[Progress in the role of intestinal goblet cells in intestinal immune regulation].

Goblet cells (GCs) are single-cell glands of humans and mammals, which are distributed in the epithelia of the respiratory tract, digestive tract, reproductive tract and so on. The mucin 2 (MUC2) in the intestine is mainly secreted by GCs. Mucin, water and inorganic salts form a mucous barrier on the surface of the intestinal mucosa, which plays an important role in resisting the invasion of foreign bacteria and intestinal microbes, maintaining the dynamic balance of intestinal mucosa and regulating the microbial-host immune response. More importantly, the defects of GCs and its secreted mucin are closely related to various diseases of the intestine. We summarized the structure and function of GCs and its research progress in intestinal immune regulation.