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Associations of SPP1 and BLK gene polymorphisms with autoimmune thyroid disease.
European Journal of Clinical Investigation 2018 December 28
BACKGROUND: Dysregulation of the type 1 interferon (IFN)-related signaling pathway predisposes one to autoimmune diseases. Possible associations of single-nucleotide polymorphisms (SNPs) of Secreted phosphoprotein 1 (SPP1) and B lymphocyte kinase (BLK) of the type 1 IFN-related signaling pathway with autoimmune thyroid disease (AITD) in an ethnic Chinese (i.e., Taiwanese) population were tested.
METHODS: Totally, 83 Hashimoto's thyroiditis (HT) patients, 319 Graves' disease (GD) patients, and 369 controls were enrolled. Genotypes of the two SNPs (rs1126772 and rs1126616) of SPP1 and two SNPs (rs13277113 and rs2736340) of BLK were determined.
RESULTS: Our results showed reduced percentages of the G allele of rs13277113 of BLK in GD (p=0.037, odds ratio (OR)=0.78, 95% confidence interval (CI)=0.62~0.99) and HT (p=0.002, OR=0.54, 95% CI=0.36~0.81), compared to the controls. At the same time, lower frequencies of the C allele of rs2736340 of BLK in GD (p=0.025, OR=0.76, 95% CI=0.60~0.97) and HT (p=0.003, OR=0.53, 95% CI=0.35~0.81) than the controls were also observed. There were significantly higher AT haplotype frequencies of rs1327713 and rs2736340 in GD and HT patients than in the controls (p=0.025, OR=1.31, 95% CI=1.03~1.67, and p=0.003, OR=1.89, 95% CI=1.24~2.87, respectively). Moreover, the anti-microsomal antibody titer was associated with rs2736340.
CONCLUSIONS: Genetic variants of rs13277113 and rs2736340 of BLK were associated with susceptibility to GD, HT, and AITD in an ethnic Chinese population. Our results suggest the BLK may participate in the pathogenesis of GD, HT, and AITD. This article is protected by copyright. All rights reserved.
METHODS: Totally, 83 Hashimoto's thyroiditis (HT) patients, 319 Graves' disease (GD) patients, and 369 controls were enrolled. Genotypes of the two SNPs (rs1126772 and rs1126616) of SPP1 and two SNPs (rs13277113 and rs2736340) of BLK were determined.
RESULTS: Our results showed reduced percentages of the G allele of rs13277113 of BLK in GD (p=0.037, odds ratio (OR)=0.78, 95% confidence interval (CI)=0.62~0.99) and HT (p=0.002, OR=0.54, 95% CI=0.36~0.81), compared to the controls. At the same time, lower frequencies of the C allele of rs2736340 of BLK in GD (p=0.025, OR=0.76, 95% CI=0.60~0.97) and HT (p=0.003, OR=0.53, 95% CI=0.35~0.81) than the controls were also observed. There were significantly higher AT haplotype frequencies of rs1327713 and rs2736340 in GD and HT patients than in the controls (p=0.025, OR=1.31, 95% CI=1.03~1.67, and p=0.003, OR=1.89, 95% CI=1.24~2.87, respectively). Moreover, the anti-microsomal antibody titer was associated with rs2736340.
CONCLUSIONS: Genetic variants of rs13277113 and rs2736340 of BLK were associated with susceptibility to GD, HT, and AITD in an ethnic Chinese population. Our results suggest the BLK may participate in the pathogenesis of GD, HT, and AITD. This article is protected by copyright. All rights reserved.
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