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Association of polymorphisms of the β-defensin 1 gene with nematode and protozoan infection traits in goat.
Parasite Immunology 2018 December 25
This study's purpose was to identify polymorphisms (SNP) in the goat β-defensin 1 gene, and to associate these SNPs with traits related to nematodean and protozoan infections in Anglo-Nubian goats from semiarid region of Brazil. 184 animals were used for DNA extraction, PCR and DNA automatic sequencing. The association analyses included the fixed effects of animal age, bloodline, and genotype of the SNP marker in the statistical model. The means of genotypes were compared by the Fisher test (P<0.05). Twelve polymorphism genotypes were found: two in intron 1, seven in exon 2 and three in 3' untranslated region. The SNPs of exon 2 were responsible for amino acid substitutions in six genetic codes, and the changes in the 25th and 33th codes affected the protein function. The SNP 1937 was significantly associated with number of protozoan oocysts, whereas SNP 2001 was associated with degree of anemia (Famacha©). Polymorphism 2046, in turn showed a significant association with Famacha© degree and number of protozoan oocysts. SNP 2140 associated with maximum EPG of the animal. Results from this study suggest that the β-defensin 1 gene can be used as a molecular marker for selection of goats regarding the susceptibility to endoparasites infections. This article is protected by copyright. All rights reserved.
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