Outcomes of Renal Allograft Recipients With Hepatitis B From January 2000 to December 2010.

OBJECTIVE: The author evaluated graft and patient outcomes of renal allograft recipients with hepatitis B infection at National Kidney and Transplant Institute from January 2000 to December 2010.

METHODS: Retrospective study with patients who underwent renal transplant with HBV infection and group of HBV-negative patients in the same post-transplantation period. Data were gathered from the patients' in-hospital and out-patient clinic records and the MEDSYS database.

RESULTS: A total of 38 renal transplant recipients were followed up. Hepatitis B cases had a 410% increased risk of having graft failure compared to hepatitis B-negative patients. The mean duration of graft survival was 145.26 (±60.40) months (12 years) in HBV negative compared to 134.29 (±67.94) months (11 years) in HBV-positive post-transplant patients. There was no difference between hepatitis B-positive and B-negative groups in terms of patient survival. The mean duration of patient survival was 156.97 (±60.62) months (13 years) in HBV negative compared to 157.37 (±61.09) months (13 years) in HBV positive post-transplant patients. There was also no significant difference in the mean values of the glomerular filtration rate and level of proteinuria between the two groups.

CONCLUSION: Although patient survival was similar in both groups, there was increased risk of graft failure in hepatitis B-positive patients.