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Impaired transplacental transfer of respiratory syncytial virus (RSV) neutralizing antibodies in HIV-infected compared to HIV-uninfected pregnant women.

HIV-exposed-uninfected infants have higher risk of respiratory syncytial virus (RSV)-associated hospitalization than HIV-unexposed infants. Despite similar neutralizing-antibody titers between HIV-infected and HIV-uninfected women, maternal HIV-infection and hypergammaglobulinemia were independently associated with lower RSV neutralizing antibody titers in the newborns. Maternal hypergammaglobulinemia was also independently associated with lower cord-to-maternal antibody ratio.

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