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Obesity and inflammation

Jacek Karczewski, Ewelina Śledzińska, Alina Baturo, Izabela Jończyk, Aleksander Maleszko, Aleksander Maleszko, Paweł Samborski, Beata Begier-Krasińska, Agnieszka Dobrowolska
European Cytokine Network 2018 September 1, 29 (3): 83-94
The prevalence of obesity has recently increased dramatically and has contributed to the increasing prevalence of various pathological conditions, including type 2 diabetes mellitus, nonalcoholic fatty liver disease, asthma, various types of cancer, cardiovascular and neurodegenerative diseases, and others. Accumulating evidence points to localized inflammation in adipose tissue, which, in turn, promotes systemic low-grade inflammation as a primary force contributing to the development of these pathologies. A better understanding of the underlying mechanisms behind obesity-induced adipose tissue inflammation is required to develop effective therapeutic or prophylactic strategies. This review is aimed to present the current knowledge of adipose tissue inflammation associated with obesity.


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