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Differential Ion Mobility Separations/Mass Spectrometry with High Resolution in Both Dimensions.
Analytical Chemistry 2018 December 14
Strong orthogonality to mass spectrometry makes differential ion mobility spectrometry (FAIMS) a powerful tool for isomer separations. However, high FAIMS resolution and 2-D FAIMS/MS peak capacity were overall achieved only with buffers rich in He or H2. That obstructed coupling to Fourier-transform mass spectrometers operating in ultrahigh vacuum, but exceptional m/z resolution and accuracy of FTMS are indispensable for frontline biological and environmental applications. By raising the waveform amplitude to 6 kV, we enabled high FAIMS resolution using solely N2 and thus straightforward integration with any MS platform - here Orbitrap XL with electron transfer dissociation (ETD) option. The initial evaluation for complete histone tails (50 residues) with diverse post-translational modifications on alternative sites demonstrates broad capability to separate and confidently identify the PTM localization variants in middle-down range.
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