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Clinical and Biophysical Outcomes of Combining Microfocused Ultrasound with Visualization and Calcium Hydroxylapatite Filler for Facial Treatment.

INTRODUCTION: Combined cosmetic treatments are becoming increasingly popular. The objective of this clinical evaluation was to assess the long-term safety and efficacy of combining microfocused ultrasound with visualization (MFU-V) treatment with a calcium hydroxylapatite (CaHA) dermal filler to tighten skin at the submental region and contour the jawline.

METHODS: Women with loss of contour and skin laxity in the lower face received MFU-V treatment. If subjects did not respond satisfactorily after 12 weeks, they received CaHA to the jawline. Evaluations-which were performed by blinded raters at baseline and after 12, 24, and 48 weeks-included live Global Aesthetic Improvement Scale (GAIS) ratings, Merz Aesthetic Scale (MAS) ratings, skin parameters, and tolerability.

RESULTS: Of the 22 subjects, 9 received combined treatments. GAIS scores showed that subjects were much and very much improved (50% each) at 48 weeks. The MAS score was decreased by at least one point in 89% of subjects. Skin thickness was significantly improved after 24 weeks (p < 0.05) and remained above baseline after 48 weeks. Skin firmness was significantly improved after 48 weeks (p < 0.05). No unexpected adverse events were reported.

CONCLUSION: Combined MFU-V and CaHA treatments for laxity in the lower face did not alter skin barrier function, improved appearance, and slowed visible skin aging processes for at least 48 weeks.

FUNDING: Merz Pharmaceuticals GmbH.

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