We have located links that may give you full text access.
Improving effect of vitamin D supplementation on obesity-related diabetes in rats.
Minerva Endocrinologica 2018 December 8
BACKGROUND: Vitamin D, a fat-soluble secosteroid, plays a key role in several metabolic diseases like diabetes. Diabetes is becoming a third leading chronic disease in the world, which seriously threatens human health.
METHODS: In current study, we found the beneficial effects of vitamin D supplementation in obesity-related diabetes rat. Enzyme-linked immunosorbent assay, biochemical testing, real-time PCR and western blot were carried to investigate the effect of vitamin D supplementation on diabetes.
RESULTS: Successful modeling of obesity-related diabetes was determined by significant weight loss and elevated levels of fasting blood glucose, glycated hemoglobin and blood lipids at 12 weeks. Supplementation of vitamin D obviously increased body weight and decreased fasting blood glucose, glycated hemoglobin, and blood lipids, accompanied by increased 25-hydroxyvitamin D and decreased insulin, parathormone and adipocytokines. Furthermore, low expressed insulin receptor substrate-1 (IRS-1)/phosphorylation of IRS-1 (p-IRS-1), glucose transporter type 4 (GluT4) and vitamin D receptor (VDR) was increased.
CONCLUSIONS: These suggested the beneficial effects of vitamin D supplementation in obesity-related diabetes rat, which may through VDR, IRS-1/p-IRS-1, and GluT4 signaling activation.
METHODS: In current study, we found the beneficial effects of vitamin D supplementation in obesity-related diabetes rat. Enzyme-linked immunosorbent assay, biochemical testing, real-time PCR and western blot were carried to investigate the effect of vitamin D supplementation on diabetes.
RESULTS: Successful modeling of obesity-related diabetes was determined by significant weight loss and elevated levels of fasting blood glucose, glycated hemoglobin and blood lipids at 12 weeks. Supplementation of vitamin D obviously increased body weight and decreased fasting blood glucose, glycated hemoglobin, and blood lipids, accompanied by increased 25-hydroxyvitamin D and decreased insulin, parathormone and adipocytokines. Furthermore, low expressed insulin receptor substrate-1 (IRS-1)/phosphorylation of IRS-1 (p-IRS-1), glucose transporter type 4 (GluT4) and vitamin D receptor (VDR) was increased.
CONCLUSIONS: These suggested the beneficial effects of vitamin D supplementation in obesity-related diabetes rat, which may through VDR, IRS-1/p-IRS-1, and GluT4 signaling activation.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Diagnosis and Management of Cardiac Sarcoidosis: A Scientific Statement From the American Heart Association.Circulation 2024 April 19
Essential thrombocythaemia: A contemporary approach with new drugs on the horizon.British Journal of Haematology 2024 April 9
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app