[THE ROLE OF INSULIN IN THE ASSESSMENT OF BONE HEALTH IN TYPE 2 DIABETES].

The purpose of this study was to identify complex relationships between the mineral, organic component of bone and the risk of fractures under the influence of metabolic changes associated with type 2 diabetes. A cross-sectional study of patients diagnosed with T2DM (n=96) was conducted; control group, consisted of 82 individuals. All patients were studied calcitropic homons, serum bone remodeling markers and bone mineral density with (DXA). In the course of this study, there was a correlation between serum insulin levels, bone metabolism markers and bone mass density determined by lumbar DXA in patients with type 2 diabetes. This allows us to believe that the presence of type 2 diabetes mellitus aggravates the disturbances of bone remodeling, thereby contributing to the development of osteoporosis. This study found that increased insulin resistance and/or hyperinsulinemia may affect the anabolic response of bone tissue, adversely affecting bone strength. Study suggests that obesity and hyperinsulinemia not be bone-protective factors, which complements the growing body of evidence that points to the importance of measuring bone remodeling markers in combination with bone mineral density in assessing and predicting the risk of fractures. Further studies are needed to determine the pathophysiological mechanisms by which insulin resistance can adversely affect bone metabolism.