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[Expression and Clinical Significance of Peripheral Blood T cell JAK2/STAT3 mRNA in Chronic Idiopathic Thrombocytopenic Purpura].

OBJECTIVE: To detect the expression of JAK2/STAT3 mRNA in peripheral blood T cells from the patients with chronic idiopathic thrombocytopenic purpura(CITP), and to explore the relationship between JAK2/STAT3 mRNA and CITP.

METHODS: CITP group and healthy control group were set in this study, The JAK2/STAT3 mRNA expression level in peropheral blood T cells of 2 groups was detected with the RT-PCR and agarose gel electrophoresis.

RESULTS: JAK2 mRNA expression level in CITP group was significantly higher than that in control group(P<0.01), the STAT3 mRNA expression level in CITP group was also higher than control group(P<0.01), The JAK2/STAT3 mRNA expression level of CITP patiants increased obviously compared with control group.

CONCLUSION: The expression level of JAK2/STAT3 mRNA increases signficanlty in chronic ITP patients, which involves in pathogenesis of CITP.

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