A Multi-Domain Continuum Model of Electrical Stimulation of Healthy and Degenerate Retina.

A continuum multi-domain model of electrical stimulation of the retina is presented and validated against retinal ganglion cell (RGC) excitation thresholds reported in a recently published in vitro experimental study. We applied our model to investigate the response of the RGC layer to electrical stimulation during mid-to-late stage retinal degeneration for both epiretinal and suprachoroidal configurations. Interestingly, our model predicted that suprachoroidal stimulation of the degenerate retina required increased current thresholds, mainly because of the presence of the glial scar layer. In contrast, epiretinal stimulation thresholds were almost similar for both healthy and degenerate models. The latter finding implies that there is no influence of the glial scar layer on epiretinal stimulation current thresholds.