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Omalizumab improves forced expiratory volume in 1 second in patients with severe asthma.

Introduction: Asthma is a multiphenotypic disease, and therapeutic managenment in patients with severe asthma is particulary difficult, with conventional treatment of severe asthma showing poor efficacy.

Aim: To analyse forced expiratory volume in 1 s (FEV1 ) following the adminstration of omalizumab.

Material and methods: Six patinents (mean age: 50 ±12.6) with severe, uncontrolled asthma according to the GINA guidelines were enrolled in the study.

Results: Treatment with omalizumab increased in all subjects FEV1 by 17.28 ±13.4% after months and 18.57 ±13.4% after 12 months of treatment.

Conclusions: These results provides further evidence that therapy with omalizumab improves spiromtric parameters in severe asthma.

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