Add like
Add dislike
Add to saved papers

Quantifying the Effect of Repeated Impacts and Lateral Tip Movements on Brain Responses during Controlled Cortical Impact.

Journal of Neurotrauma 2019 Februrary 8
Controlled cortical impact (CCI) is a widely used laboratory neurotrauma model to study traumatic brain injury. During CCI, the brain is damaged by an impactor tip, which travels along its axial direction to a pre-defined depth at a pre-set speed. A recent study, however, using high-speed imaging analysis demonstrated that the impactor tip of an electromagnetically driven CCI device experienced repeated impacts and lateral movements, rather than a single axial impact. How these repeated impacts and lateral movements affect internal brain stresses/strains-which are the direct cause of neuronal damage and affect the accuracy and reproducibility of CCI-remains unknown. We use a previously validated, highly detailed three-dimensional finite element (FE) mouse brain model to investigate the effect of repeated impacts and lateral movements on brain responses during CCI. We also measured tip movements of an in-house pneumatically driven CCI and conducted FE simulations. We found that the repeated impacts had minimal effect on peak strains. The lateral movements of the tip, however, greatly increased brain strains and affected large brain regions. Hence, it is necessary to monitor and control lateral movements to ensure the accuracy and reproducibility of CCI.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app