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The use of "QUAD Shot" in Anal Canal Squamous Cell Carcinoma: A Case Study with Review of the Literature.

CONTEXT: Patients with locoregional anal carcinoma who don't qualify for standard definitive chemoradiation are candidates for a short course of palliative hypofractionated radiotherapy such as QUAD Shot.

METHODS: A 57-year-old man with massive locoregional squamous cell carcinoma of the anal canal was treated with QUAD Shot (14.8 Gy in 4 fractions over 2 consecutive days) repeated every 4 weeks for a total of 2 courses.

RESULTS: He reported symptomatic relief following each course of radiation. In regard to his first QUAD Shot, his pain was 10/10 in severity at the time of admission and 4/10 at the time of discharge. In regard to his second QUAD Shot, his pain was 8/10 at the time of admission and 0/10 at the time of discharge. He did not experience any treatment related toxicity. He passed away 15 weeks after the first course.

CONCLUSION: QUAD Shot is both efficacious and safe for palliation in patients with anal carcinoma.

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