Synthesis and characterization of hybrid Anderson hexamolybdoaluminates(III) functionalized with indometacin or cinnamic acid.

The single-side Al-centred tris-functionalized hybrid organic-inorganic Anderson polyoxomolybdates (C16 H36 N)3 [Al(OH)3 Mo6 O18 (OCH2 )3 CNH(C10 H8 O)]·C9 H7 N·4CH3 OH·5H2 O (AlMo6 -NH-Cin; Cin is cinnamic acid, C10 H9 O2 ) and (C16 H36 N)3 [Al(OH)3 Mo6 O18 (OCH2 )3 CNH(C19 H15 ClNO3 )]·9H2 O (AlMo6 -NH-Indo; Indo is indometacin, C19 H16 ClNO4 ) have been prepared in a mild three-step synthesis and structurally characterized by single-crystal X-ray diffraction, 1 H NMR and IR spectroscopies and elemental analysis. Both AlMo6 -NH-Cin and AlMo6 -NH-Indo crystallize in the orthorhombic space group Pbca. The antibacterial activities of AlMo6 -NH-Cin and AlMo6 -NH-Indo against the Gram-negative human mucosal pathogen Moraxella catarrhalis were investigated by determination of the minimum inhibitory concentration, which is 32 µg ml-1 for AlMo6 -NH-Cin and 256 µg ml-1 for AlMo6 -NH-Indo.