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Cytotoxic Effects of Some Flavonoids and Imatinib on K562 Chronic Myeloid Leukemia Cell Line: Data Analysis Using the Combination Index Method.

Balkan Medical Journal 2018 November 6
BACKGROUND: Although water pipe smoking is a great public health problem, data regarding the acute and chronic effects and the degree of toxin exposure are limited. While water pipe-related malignancy, pulmonary, infectious, cardiac effects, infertility and biological effects have been described in a meta-analysis, there are no studies in the literature about its neurologic effects.

AIMS: The aim was to evaluate water pipe-related acute neurological effects and cerebral blood flow through transcranial doppler ultrasonography and serum s100b protein level measurements.

STUDY DESIGN: This prospective observational study was conducted with healthy volunteers at a hookah café above the 18 years.

METHODS: Vital signs and baseline carboxyhemoglobin (COHb) and S100b levels, cerebral flood changes with Transcranial Doppler Ultrasound were evaluated and recorded before and after water-pipe smoking.

RESULTS: The mean age of the 31 volunteers was 30,61 (±5,67) years and 24 of them (77,42%) were male. A statistically significant difference was determined in heart rate, oxygen saturation, systolic and diastolic arterial pressure values before and after water pipe smoking (p<0,001, p=0,035, p=0,009, p=0,021, respectively). Mean COHb level was 2,68 % (±1,68) before, 14,97 % (±4,83) after water pipe smoking (p<0,001). The S100b protein level was 25,05 µ/ml (±8,34) at the beginning, 40,71 µ/ml (±14,06) after water pipe smoking (p<0,001). An increase was determined in peak and median middle, anterior and posterior cerebrale artery blood flow rates, and a decrease was determined in the pulsatility index and resistivity index values after water pipe smoking through transcranial Doppler ultrasound.

CONCLUSION: Cerebral vasodilation develops due to the increase in cerebral blood flow rate and the decrease in pulsatility index, resistivity index values, and the elevation in COHb, S100b level indicates that water pipe smoking leads to neuron damage in the acute period.

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