Cardiotoxicity associated with Midazolam in a patient with Diphtheria.

Adverse cardiorespiratory events are associated with its continuous iv infusion used for sedation. Here we are reporting a case of 5 year old male child suffering from diphtheria, who received midazolam in the form of iv infusion for sedation. Six hours after starting midazolam infusion he started developing pulsus bigeminus and bradycardia and eventual death. Midazolam, although considered as one of the safest drugs, need to be used cautiously because of the possible cardiotoxic effect in an already affected heart.