Add like
Add dislike
Add to saved papers

Macular Inner Retinal Layer Thinning in Diabetic Patients without Retinopathy Measured by Spectral Domain Optical Coherence Tomography.

The aim of this study was to use Spectral Domain-Optical Coherence Tomography (SD-OCT) to measure the thickness of the Macular Inner Retinal Layer (MIRL) and compare the results between diabetic patients with no signs of retinopathy and healthy subjects. Overall, 47 type 2 diabetic patients without clinical signs of retinopathy were prospectively analyzed along with 36 healthy subjects. This study excluded patients with other systemic or ocular diseases. All patients had their MIRL thickness measured by RTVue-100 SD-OCT (7x7 mm macular grid). The MIRL thickness is provided by the ganglion cell complex scan (comprised of the retinal nerve fiber, ganglion cell, and inner plexiform layers). Only one eye was randomly selected if both were eligible for analysis. Mean age was similar between the two groups (diabetic patients: 57.3 ± 10.6 and control subjects: 60.2 ± 12.2 years) (P = 0.19). No significant differences regarding optic disc area and cup-to-disc ratio was observed in the comparison of the two groups (P ≥ 0.38 for both comparisons). In patients with diabetes, the average MIRL was significantly thinner when compared to controls (91.6 versus 96.2 micrometer (µm); P = 0.02). Regional analysis revealed superior and inferior MIRL to be significantly thinner in patients with diabetes than the controls (P ≤ 0.04). The juxtafoveal area was compromised (thinned) in 70% of diabetic eyes, classified as abnormal (P < 1%; compared to the device's normative database). In conclusion, patients with type 2 diabetes without clinical evidence of retinopathy had lower MIRL average values when compared to the control group. This can be explained by the ischemia and retinal tissue injury caused by diabetes even in early stages of diabetic retinopathy, which can affect MIRL thickness. Possible implications of these findings on diagnosis and treatment of diabetic retinopathy requires further investigation.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app